1Radio-Chemotherapy Department, Zhongnan Hospital of Wuhan University, Wuhan 430071, China; 2
Cancer Center, Renmin
Hospital of Wuhan University, Wuhan 430060, China
Abstract：Through slow and long-term gene-environment interactions, environmental factors (such as nutritional factors,
physical and chemical factors, patterns of life, etc.) might cause genetic mutation and affected drug-sensitivity, thus might affect
the choice or the treatment efficacy of tumor-targeted therapy. Nutritional status before cancer treatment had been considered as an
important prognostic factor in cancer chemotherapy and radiotherapy. However, in the era of cancer molecular-targeted therapy, its
prognostic values have often been ignored. As far as we known, there was no study specifically address the roles of environmental
factors including nutritional factors on tumor-targeted therapy. To throw some light on this emerging research area and provid more
basis for molecular-targeted therapy of clinical oncology, we made an review about the research progress in the effects of nutritional
factors on tumor-targeted therapy.
