Abstract：Abstract: Stimulated by growth factors, hormone and other signals, mTOR plays a critical role in regulating cell proliferation and differentiation. We reviewed and analyzed literatures, then argued that the methylation of key genes in mTOR signaling pathway could result in abnormal energy metabolism in cancer, producing aerobic glycolysis, and interfering with protein hydrolysis. Demethylating genes in mTOR signaling pathway, which might be an entry point to reverse the abnormal energy metabolism in cancer.
李洁茹;马怀幸;李苏宜. mTOR 通路基因甲基化与肿瘤能量代谢[J]. 肿瘤代谢与营养电子杂志, 2016, 3(3): 186-190.
LI Jie-ru;MA Huai-xing;LI Su-yi. The methylation of gene in mTOR pathway and tumor energy metabolism. Electronic Journal of Metabolism and Nutrition of, 2016, 3(3): 186-190.
