Abstract：Objective Exploring the efficacy evaluation of medical tissue glue combined with microwave ablation in the treatment of
peripheral lung cancer. Method A prospective study design was adopted. A total of 105 patients with peripheral lung cancer who met
the inclusion criteria and were admitted to Bayingolin Mongolian Autonomous Prefecture People 's Hospital from January 2021 to
December 2023 were selected. They were divided into an observation group n = 53 and a control group n = 52 using a random
number table method. The control group was treated with microwave ablation while the observation group was treated with microwave
ablation combined with medical tissue glue. The clinical efficacy of the two groups was compared after 3 years of follow-up the
survival rate and recurrence rate of the two groups were statistically analyzed the Cox proportional hazards regression model was used to
analyze the prognostic factors and the quality of life and incidence of complications of the two groups were compared. Result After 1
month of treatment the complete ablation rate disease control rate DCR and objective response rate ORR in the observation
group were significantly higher than those in the control group P <0. 05 . After 3 years of follow-up the overall survival OS and
progression-free survival PFS in the observation group were higher than those in the control group while the local recurrence rate
was lower than that in the control group P <0. 05 . Cox regression analysis showed that combined treatment and tumor diameter ≤3 cm
were independent protective factors for OS. Stratified analysis showed that the combined therapy had a more significant therapeutic
effect on patients with tumor diameter ≤3 cm P <0. 05 . After 3 months of treatment the quality of life score in the observation
group was higher than that in the control group P <0. 05 . The total incidence of complications in the observation group was lower
than that in the control group and no severe complications occurred. Conclusion The combination of medical tissue glue and
microwave ablation in the interventional treatment of peripheral lung cancer has better efficacy than microwave ablation alone. It can
reduce the recurrence rate of patients improve their 3-year survival rate.
王 魁,谭永华,梁光聪. 医用组织胶联合微波消融治疗周围型肺癌的疗效评估[J]. 肿瘤代谢与营养电子杂志, 2025, 12(6): 779-785.
Wang Kui, Tan Yonghua, Liang Guangcong. Efficacy evaluation of medical tissue adhesive combined with microwave ablation in interventional treatment of peripheral
lung cancer. Electron J Metab Nutr Cancer, 2025, 12(6): 779-785.
