1Department of General Surgery Kailuan General Hospital Affiliated to North China University of Science and Technology Tangshan
063000 Hebei China
2Graduate School of North China University of Science and Technology Tangshan 063000 Hebei China
Abstract：Objective To investigate the association between Chinese visceral adiposity index CVAI and the risk of colorectal
cancer CRC . Method In-service and retired employees who participated in the health checkup of Kailuan Group in 2006 were
selected for this study and 98 311 participants were finally included. According to the tertile of CVAI the study subjects were divided
into CVAI1 group ≤75. 36 CVAI2 group 75. 36~ 108. 30 and CVAI3 group >108. 30 . Participation in a physical examination
was used as the starting point for follow-up and study participants were followed up with newly diagnosed CRC as the outcome event
and the occurrence of the outcome event death or the end of the follow-up time as the follow-up endpoint. The cumulative incidence
of CRC in each group was calculated using the Kaplan-Meier method and the incidence curves were plotted and the log-rank test was
used for comparison between groups. The Cox proportional risk regression model was used to analyze the hazard ratio HR and 95%
confidence interval CI of CRC incidence by different CVAI. The receiver operating characteristic curve ROC of the subjects was
established and the predictive performnce of CVAI and traditional obesity indices for CRC was compared by calculating the area under
the ROC curve AUC of CVAI visceral adiposity index VAI body mass index BMI and waist circumference WC . Result As
the CVAI increased the cumulative incidence of CRC increased and the difference was statistically significant by log-rank test
χ
2 =
72. 84 P< 0. 001 . The results of multivariable Cox proportional hazard regression model analysis showed that after correcting for
relevant confounders the risk of CRC incidence was increased by 1. 27-fold 95%CI = 1. 02 ~ 1. 58 in the CVAI3 group compared
with that in the CVAI1 group respectively. AUCCVAI
= 0. 66 0. 64~ 0. 68 AUCWC
= 0. 65 0. 63~ 0. 66 AUCBMI
= 0. 65 0. 63 ~ 0. 66
AUCVAI
= 0. 65 0. 63 ~ 0. 66 AUCCVAI > AUCWC
AUCVAI
AUCBMI
. Conclusion Higher CVAI level is an independent risk factor for
CRC and the risk of CRC increases with increasing CVAI CVAI has a higher predictive ability for CRC than VAI BMI and WC.
1,2陆燚,1 戴世龙,1 王明君,1 周静,1,2 郝君颖,1 张青松. 中国内脏脂肪指数与结直肠癌发病风险的相关性:一项前瞻性研究[J]. 肿瘤代谢与营养电子杂志, 2025, 12(5): 594-601.
1,2Lu Yi,1Dai Shilong,1Wang Mingjun,1Zhou Jing,1,2Hao Junying,1Zhang Qingsong. CVAI is more closely associated with risk of colorectal cancer than traditional obesity indicators. Electron J Metab Nutr Cancer, 2025, 12(5): 594-601.
