Mechanisms of action and nutritional intervention strategies of plant compounds regulating metabolic reprogramming in
tumors research progress and perspectives
Xiang Xinyu, Song Dingka, Li Xiaoguang
Shanghai Jiaotong University School of Medicine Shanghai 200025 China
Abstract：Tumor metabolic reprogramming is one of the most critical scientific questions in cancer research which is
characterized by tumor cells supporting malignant proliferation and metastasis by remodeling themselves and microenvironmental
metabolic pathways. In recent years the potential role of plant compounds for tumor metabolism intervention have been unraveled due
to their diverse biological activities and multi-targeting ability. Recent studies have shown that plant compounds is beneficial in the
metabolic reprogramming of tumor cells by regulating the activity of critical metabolic enzymes inhibiting aberrant signaling pathways
remodeling tumor microenvironment thereby inhibiting tumor growth and metastasis. In this paper we systematically reviewed the
latest research of plant compounds in tumor metabolic regulation focusing on their effects on core metabolic pathways such as
glycolysis oxidative phosphorylation lipid metabolism amino acid metabolism and analyzed their mechanism of action in tumor
microenvironment. We also summarized current challenges for the clinical translation of plant compounds including limited delivery
strategies complexed mechanisms etc. Basing on multi - omics technology nano - delivery as well as other cutting - edge
technologies we are looking forward to the clinical application of plant compounds in cancer prevention and treatment in the future.
向鑫雨,宋丁卡,李晓光. 植物化合物调控肿瘤代谢重编程的作用机制及营养干预策略:研究进展与展望[J]. 肿瘤代谢与营养电子杂志, 2025, 12(5): 535-541.
Xiang Xinyu, Song Dingka, Li Xiaoguang. Mechanisms of action and nutritional intervention strategies of plant compounds regulating metabolic reprogramming in
tumors research progress and perspectives. Electron J Metab Nutr Cancer, 2025, 12(5): 535-541.
