Research progress of ceRNA regulatory network related positive feedback loop in gastric cancer
1Chen Yuhao,1Han Jingxiang,1Gao Linna,1Gao Huiyang,2Yao Tian,1,2Huang He
1
The First Clinical Medical College Shanxi Medical University Taiyuan 030001 Shanxi China
2Department of Gastrointestinal
Surgery the First Hospital of Shanxi Medical University Taiyuan 030001 Shanxi China
Abstract：Gastric cancer severely affects human health and has become a significant health issue of global concern. In its complex
pathogenesis genetic regulatory networks play an important role. Among them the competitive endogenous RNA ceRNA regulatory
network is an important field of research. This network involves the interaction between various types of RNA molecules including
mRNA miRNA lncRNA and circRNA etc. They precisely control gene expression through complex regulatory mechanisms thereby
affecting the occurrence and development of gastric cancer. Positive feedback loops are indispensable signaling mechanisms within
biological systems they accelerate or amplify specific biological processes by cyclically enhancing initial signals. They play a crucial
role not only in cell growth development and response to various physiological and pathological stimuli but also participate in the
occurrence and development of tumors in many ways such as promoting the proliferation and invasion of tumor cells changing the
tumor microenvironment and increasing the chemoresistance of tumor cells. Positive feedback loops also exist within the ceRNA
regulatory network. These loops potentially drive the occurrence and development of gastric cancer by amplifying specific signals to
regulate key processes such as cell proliferation apoptosis migration and invasion. Therefore in - depth study of the positive
feedback loops related to the ceRNA regulatory network is of great significance for revealing the pathogenesis of gastric cancer and
discovering new potential therapeutic targets. This article reviews the role and molecular mechanisms of ceRNA - related positive
feedback loops in gastric cancer and looks forward to their application prospects in the treatment of gastric cancer.
