Analysis of the epidemiological characteristics of vitamin deficiency in patients with digestive system tumors based on clinical
data from 13 463 patients
Li Jiawei, Xu Wenwen, Xie Yin, Yu Xiang, Wang Chen, Zheng Xuan
Abstract：Objective This study aims to investigate the levels of various serum vitamins in patients with digestive system tumors
analyze the differences in vitamin deficiencies among different categories of tumor patients and further explore the correlation between
serum vitamin levels protein indicators and inflammation indicators. This research aims to provide a scientific basis for vitamin
supplementation in clinical patients with digestive system tumors. Methods We collected the results of serum vitamin tests for 13 463
in-patients with digestive system tumors in Changhai Hospital from January 2018 to June 2023. Statistical software SPSS 21. 0 was used
for variance analysis to compare serum vitamin levels and chi-square tests were conducted to analyze the differences in deficiency
rates of various vitamins in different types of digestive system tumors. Additionally Spearman correlation analysis was employed to
investigate the correlation between serum vitamins and protein and inflammation indicators Results Digestive system tumor patients
significantly lack water-soluble vitamins vitamin B1
vitamin C and vitamin B6
with an overall deficiency rate of 67. 75% 61. 51%
and 32. 17% respectively. The significant deficiency of fat-soluble vitamin vitamin D is observed with an overall deficiency rate of
63. 60%. The deficiency rates of vitamin B1
in esophageal cancer gastric cancer colorectal cancer and pancreatic cancer are
significantly higher than those in liver cancer patients 69. 11% 69. 03% 72. 62% 74. 14% vs. 18. 41% P < 0. 001 . The serum
folate deficiency rate in liver cancer patients is much higher than in the above four types of digestive system tumor patients 46. 44%
vs. 9. 02% 13. 13% 12. 82% 5. 70% P < 0. 001 . Spearman correlation analysis demonstrates that the levels of serum vitamin C
and vitamin B6
in digestive system tumor patients are positively correlated with serum albumin vitamin C r = 0. 207 P < 0. 001
vitamin B6
r = 0. 255 P < 0. 001 . vitamin A is negatively correlated with IL-1β r = -0. 306 P < 0. 01 vitamin B6
is negatively
correlated with IL-6 r = -0. 265 P < 0. 01 and vitamin C is negatively correlated with TNF-α r = - 0. 203 P < 0. 05 .
Conclusion Different types of digestive system tumors exhibit distinct patterns of vitamin deficiencies. Clinically it is essential to develop corresponding nutritional supplementation plans based on their metabolic characteristics and to pay attention to the impact of
inflammation on vitamin consumption.
李嘉伟,徐雯雯,谢 印,余 翔,王 晨,郑 璇. 消化系统肿瘤患者维生素缺乏的流行病学特点分析———基于 13 463 例患者的临床信息[J]. 肿瘤代谢与营养电子杂志, 2024, 11(6): 854-863.
Li Jiawei, Xu Wenwen, Xie Yin, Yu Xiang, Wang Chen, Zheng Xuan. Analysis of the epidemiological characteristics of vitamin deficiency in patients with digestive system tumors based on clinical
data from 13 463 patients. Electron J Metab Nutr Cancer, 2024, 11(6): 854-863.
