Clinical study on the correlation between body fluid distribution and radiation oral mucositis in patients with head and neck
cancer undergoing radiotherapy based on bioelectrical impedance analysis
1Department of Radiotherapy Jiangsu Province Hospital of Chinese Medicine Affiliated Hospital of Nanjing University of Chinese
Medicine Nanjing 210029 Jiangsu China
2Department of Geriatrics Taikang Xianlin Drum Tower Hospital Nanjing
210000 China
Abstract：Objective Bioelectrical impedance analysis BIA was used to observe the fluid distribution of patients with head and
neck cancer who were undergoing radiotherapy including intracellular water extracellular water total body water ECW/ ICW %
ECW/ TBW % changes. At the same time by observing the occurrence time and degree of radiation oral mucositis ROM during
radiotherapy the correlation between the fluid distribution and the occurrence and degree of ROM was analyzed. Method A total of 60
patients with head and neck caner who were undergoing radiotherapy in the Radiotherapy Department of Jiangsu Province Hospital of
Chinese Medicine from September 2022 to March 2024 were prospectively included. fluid distribution indicators such as ICW ECW
TBW ECW/ ICW % and ECW/ TBW % were collected and recorded before at the 2nd 4th and 6th week and finished day of
radiotherapy respectively. To observe the occurrence time and severity of oral mucositis during radiotherapy RTOG radiation damage
grading standard and explore the correlation between them. Result The values of ICW ECW and TBW varied with the degree of ROM
at the 4th week of radiotherapy. ICW values in patients with OM grade 3 or higher were significantly lower than those with OM grade 2
or lower P < 0. 05 while ECW ECW/ ICW % and ECW/ TBW % values were increased significantly P < 0. 05 . No
correlations were found between fluid distribution and ROM occurrence in other time. Conclusion The fluid distribution of patients with
head and neck cancer during radiotherapy was significantly related to the occurrence and degree of radiation oral mucositis. The
characteristics of human fluid distribution based on BIA measurement may be used as a potential predictor of radiation-induced oral
mucositis which has great clinical significance for screening patients with high risk of ROM and prior intervention before symptoms
occur.
1刘 婕,1赵 迪,2赵悦欣,1鹿 红,1卞新禹,1王 培. 基于生物电阻抗法分析头颈部肿瘤放疗患者机体液体分布与发生放射性口腔黏膜炎相关性的临床研究[J]. 肿瘤代谢与营养电子杂志, 2024, 11(6): 834-839.
1Liu Jie,1Zhao Di,2Zhao Yuexin,1Lu Hong,1Bian Xinyu,1Wang Pei. Clinical study on the correlation between body fluid distribution and radiation oral mucositis in patients with head and neck
cancer undergoing radiotherapy based on bioelectrical impedance analysis. Electron J Metab Nutr Cancer, 2024, 11(6): 834-839.
