1Department of Otolaryngology Head and Neck Surgery West China Hospital of Sichuan University / West China School of Nursing
Sichuan University Chengdu 610041 Sichuan China
2 Department of Otolaryngology Head and Neck Surgery West China Tianfu
Hospital Sichuan University Chengdu 610020 Sichuan China
Abstract：Objective To explore the prognostic association of malnutrition and NPC patients based on GLIM criteria and the
prediction model construction. Method A total of 185 NPC patients were collected from January 2022 to January 2023 and were divided
into two groups based on GLIM criteria namely malnutrition group n = 72 and no malnutrition group n = 113 . Compared with
general data malnutrition factors were affected by binary Logistic regression analysis. After another 12-month follow-up association
with nutritional status by Cox proportional risk Kaplan-Meier survival analysis and ROC curve analysis of malnutrition based on
GLIM criteria. Result After binary Logistic regression analysis age ≥ 60 years OR = 2. 393 TNM stage Ⅲ ~ Ⅳ OR =
2. 053 ≥3 gastrointestinal symptoms OR = 2. 288 and chemoradiotherapy OR = 2. 097 were independent risk factors for
malnutrition in NPC patients P <0. 05 . After a 12-month follow-up visit 66 progression-free survival in the malnutrition group
112 control subjects with progression-free survival according to the Kaplan-Meier survival analysis statistical difference in death /
recurrence rate and survival time between the two groups P <0. 05 After the Cox proportional risk analysis Malnutrition was an
independent factor affecting the prognosis of NPC patients P <0. 05 After the ROC curve analysis Assessment of malnutrition based
on GLIM criteria in predicting NPC prognosis AUC = 0. 743 S. E. = 0. 083 P = 0. 029 95% CI = 0. 580 - 0. 907 sensitivity of
85. 7% specificity of 62. 9% the Youden index is set at 0. 486 indicating a high predictive efficacy of malnutrition assessment based
on the GLIM criteria. Conclusion The nutritional status of nasopharyngeal cancer patients will be affected by age tumor TNM
digestive tract symptoms and radiotherapy and chemotherapy. For high-risk factors precise prevention and rehabilitation should be
required to reduce the malnutrition rate. At the same time it is necessary to focus on monitoring the malnutrition status based on GLIM
standards timely detect malnutrition and guide clinical intervention to improve the prognosis.
1徐 婷,2林佳佳,2赖建月,2程 梅,1赵会玲. 基于全球领导人营养不良倡议标准的营养不良与鼻咽癌患者预后关联及预测模型构建[J]. 肿瘤代谢与营养电子杂志, 2024, 11(4): 519-524.
1Xu Ting,2Lin Jiajia,2Lai Jianyue,2Cheng Mei,1Zhao Huiling. Prognostic association and prediction model construction of malnutrition and NPC patients based on GLIM criteria. Electron J Metab Nutr Cancer, 2024, 11(4): 519-524.
