Research on the role of fatty acids in cancer prevention and treatment
1He Yannan,2Zhao Feng,3Liu Yinghua
1
Institute of Nutrition and Health of Qingdao University Qingdao 266021 Shandong China
2Center of Lipid and Diseases Suzhou
Institute of Industrial Technology Zhejiang University Hangzhou 215163 Zhejiang China
3Department of Nutrition the First
Medical Center of the PLA Hospital Beijing 100853 China
Abstract：The correlation between dietary intake and fatty acid profile within the human body significantly impacts tumor
development. Carbohydrates proteins and fats influence fatty acid metabolism. Adjusting dietary fatty acid including palmitic acid
intake and unsaturated fatty acid consumption may improve the gastrointestinal anti - inflammatory milieu and overall health. An
increased intake of leafy greens supplies alpha-linolenic acid and enriches dietary fiber thereby supporting the diversity and balance of
the gut microbiota. Elevating ω-3 fatty acid levels has been shown to optimize gut flora reduce inflammation and decrease tumor
risk. Conversely a high dietary proportion of ω - 6 fatty acids may exacerbate intestinal inflammation and potentially facilitate
tumorigenesis. ω- 3 PUFAs inhibit tumor cell proliferation and promote apoptosis mitigating tumor risk by antagonizing the pro -
inflammatory effects of ω-6 PUFAs. Managing the ratios of ω-6 ∶ ω-3 and arachidonic acid ∶ EPA helps reducing the incidence of
chronic diseases and tumors. The effects of trans fats and saturated fats are linked to increased tumor risks whereas the influence of
monounsaturated fats remains variable necessitating further investigation. In summary strategic management of dietary fatty acids
regulate intestinal health mitigate inflammatory responses and positively influence tumor prevention and treatment offering new
avenues for cancer management strategies.
1何雁南,2赵 锋,3刘英华. 脂代谢平衡防治肿瘤发生、发展的研究进展[J]. 肿瘤代谢与营养电子杂志, 2024, 11(4): 473-479.
1He Yannan,2Zhao Feng,3Liu Yinghua. Research on the role of fatty acids in cancer prevention and treatment. Electron J Metab Nutr Cancer, 2024, 11(4): 473-479.
