Association of FOXP3
+
tumor infiltrating lymphocytes with poor prognosis of primary breast cancer a retrospective
cohort study
Zhao Xia, Li Yanping, Feng Yu, Lyu Shuzhen
Department of Surgical Breast Cancer Capital Medical University Cancer Center Beijing Shijitan Hospital Capital Medical University
Beijing 100038 China
Abstract:Objective To detect the expression of FOXP3
+
TILs in primary invasive breast cancer analyze the correlation between
the expression level of FOXP3
+
TILs and the clinicopathological characteristics of breast cancer and explore the relationship between
FOXP3
+
TILs and the prognosis of breast cancer. Method Surgically resected samples from 156 patients with invasive breast cancer
BC were assessed for the expression of FOXP3
+
TILs and CD4
+
TILs by immunohistochemistry. The correlation between FOXP3
+
TILs
and the patients ' clinicopathological characteristics was explored. Kaplan - Meier survival analysis and Cox proportional hazards
regression model were used to assess the correlation between FOXP3
+
TILs and breast cancer-specific survival and to stratify the
evaluation of breast cancer subtypes. Result Elevated FOXP3
+
TILs infiltration were significantly correlated with high histological grade
P= 0. 021 positive human epidermal growth factor receptor-2 HER-2 P=0. 018 Progesterone receptor expression PR P=0. 016
high Ki-67 index P = 0. 042 and axillary lymph node metastases P = 0. 001 . There was no significant correlation between CD4
+
TILs
expression and the clinicopathological features of all patients. Tumors with concomitant high expressions of FOXP3
+
TILs had worse overall
survival OS and disease-free survival DFS 64. 7% vs 87. 6%
χ
2 = 15. 3 P<0. 001 56. 9% vs 80. 0%
χ
2 = 13. 1 P<0. 001 . The patients
with axillary lymph node metastases with the high expressions of FOXP3
+
TILs infiltration had worse DFS P<0. 001 . Multivariate analysis
showed that FOXP3
+
TILs was independent predictors of OS HR=2. 732 95%CI=1. 174~6. 207 P=0. 023 and DFS HR=2. 092 95%CI=
1. 068~4. 088 P = 0. 032 . Conclusion The high expression of FOXP3
+
TILs in breast cancer is associated with tumor progression higher
expression of FOXP3
+
TILs indicates wores OS and DFS FOXP3
+
TILs maybe a prognostic marker for breast cancer.
赵 霞,李艳萍,冯 宇,吕淑贞. FOXP3
+ 肿瘤浸润性淋巴细胞与乳腺癌病理特征和预后
的相关性研究[J]. 肿瘤代谢与营养电子杂志, 2024, 11(3): 414-420.
Zhao Xia, Li Yanping, Feng Yu, Lyu Shuzhen. Association of FOXP3
+
tumor infiltrating lymphocytes with poor prognosis of primary breast cancer a retrospective
cohort study. Electron J Metab Nutr Cancer, 2024, 11(3): 414-420.