The research advance on intermittent fasting to improve cognitive impairment associated with Alzheimer's disease
Ren Qiwei,Jiang Jiwei, Xu Ju
Department of Cognitive Impairment Neurology Center Beijing Tiantan Hospital Capital Medical University National Clinical Research Center for Neurological Diseases Beijing 100070 China
摘要近年来,越来越多的证据提示膳食营养干预在改善阿尔茨海默病(Alzheimer's disease,AD)相关认知障碍临床症状
和整体预后中的重要地位。 最新研究证实,间歇性禁食(intermittent fasting,IF)可以改善 AD 小鼠模型的认知功能和 AD 特异
性病理改变,为 AD 的治疗提供了新的机会。 临床研究也表明,IF 可以显著提高轻度认知障碍患者的认知评分。 然而,尽管有
一定的研究基础,国内外对于 IF 临床应用的潜在机制和科学原理认识仍处于初步阶段。 IF 是否可以改善 AD 相关认知障碍
患者的认知、情绪、精神行为异常等临床表现尚不十分明确。 因此,本文拟探讨 IF 改善 AD 临床表现的可能性及其潜在机
制,旨在为 AD 治疗提供新的可能治疗思路及依据。
Abstract：In recent years there is growing evidence that dietary nutritional interventions are important in improving the clinical
symptoms and overall prognosis of cognitive impairment associated with Alzheimer's disease AD . Recent studies have confirmed that
intermittent fasting IF can improve cognition function and AD-specific pathological change in AD mouse models. That offers a new
opportunity for the treatment of AD. The clinical study has also shown that IF can significantly improve cognitive scores in patients with
mild cognitive impairment. Despite a certain research base the understanding of the potential mechanisms and scientific principles of
IF clinical application is still at a preliminary stage. It is not clear whether IF can improve the clinical performance of patients with
AD-related cognitive impairment such as cognitive emotional and psychobehavioral symptoms. Therefore this review intends to
explore the possibility and potential mechanisms of IF to improve the clinical performance of AD aiming to provide a new possible
therapeutic idea and basis for AD treatment.
